Glycocholic Acid Sodium Salt

SKU: orb1221719

Description

Glycocholate sodium is a conjugated bile salt and ionic biologic detergent. It is involved in the emulsification of fats.

Key Properties

• CAS Number: 863-57-0
• MW: 487.61
• Purity: >98% (HPLC)
• Formula: C₂₆H₄₂NNaO₆
• SMILES: [Na+].[O-]C(=O)CNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
• Target: Others
• Solubility: In Vitro: DMSO : ≥ 100 mg/mL (205.09 mM)

Bioactivity

• In Vitro:
  Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Glycocholate sodium | Glycocholic acid sodium salt

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Gene Symbol

Others