GLX351322

SKU: orb1299213

Description

GLX351322 is a potent and selective NADPH oxidase 4 (NOX4) inhibitor with an IC50 value of 5 µM. This small molecule is a valuable research tool for investigating the role of NOX4-derived reactive oxygen species in pathologies such as fibrosis, cancer, and diabetic nephropathy in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 835598-94-2
• MW: 431.51
• Purity: 99.93% (May vary between batches)
• Formula: C₂₁H₂₅N₃O₅S
• SMILES: CCOC(=O)c1c(NC(=O)CN2CCN(CC2)C(=O)c2ccco2)sc2CCCc12
• Target: NADPH-oxidase,NADPH
• Solubility: DMSO:20 mg/mL (46.35 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.32 mM)

Bioactivity

• Target IC50:
  NOX2:40 μM|NOX4:5 μ M
• In Vitro:
  In long-term experiments (1-3 days), high-glucose-induced human islet cell reactive oxygen species (ROS) production and death were prevented by GLX351322.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NADPH Oxidase, NADPHoxidase, inhibit, NOX4, NOX, Inhibitor, GLX 351322, GLX351322, GLX-351322

Compound Identifiers

PubChem CID

2697686