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β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE

SKU: orb1944071

Description

This β-glucuronide-MMAE conjugate (compound 20) demonstrates potent in vitro antiproliferative activity (IC50 5.7-9.7 nM) against cancer cells and shows significant in vivo antitumor efficacy in HCT-116 xenograft models without observed side effects, supporting its research in antibody-drug conjugate (ADC) prodrug and targeted cancer therapy.

Images & Validation

Key Properties

TargetDrug-Linker Conjugates for ADC

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information