α-Glucosidase-IN-79

SKU: orb2945622

Description

α-Glucosidase-IN-79 (Compound 4d9) is a non-competitive α-glucosidase inhibitor with an IC50 of 2.11 μM, demonstrating greater inhibitory potency than the existing α-glucosidase inhibitors Acarbose (IC50 of 327.0 μM) and HXH8r (IC50 of 15.32 μM). It exhibits no cytotoxicity on normal human liver cells (LO2) and shows good metabolic stability in rat plasma. α-Glucosidase-IN-79 holds promise for research in type 2 diabetes.

Images & Validation

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Key Properties

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MW	414.475
Formula	C₂₁H₂₂N₂O₅S
SMILES	CC1CCC2=C(C1)SC(=C2C#N)NC(=O)COC3=CC(=CC(=C3OC)OC)C=O
Target	glycosidase

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

glycosidase

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