Glucocorticoid receptor/IL-6-IN-1

SKU: orb3173428

Description

Glucocorticoid receptor/IL-6-IN-1 (Compound 35) is a selective dual inhibitor of the glucocorticoid receptor (GR) and the IL-6 signaling pathway, with IC50 values of 120 nM and 59 nM, respectively. It suppresses IL-6-induced phosphorylation of JAK/STAT3, thereby blocking the transcription of inflammatory cytokines. This compound holds potential for research into inflammatory diseases such as rheumatoid arthritis and asthma.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1198784-71-2
• MW: 501.5
• Formula: C₂₂H₂₃F₄N₃O₄S
• SMILES: O=C(N)C1=CC(F)=CC=C1C(C)(C)CC(O)(CC2=CC=3C=C(N=CC3N2)S(=O)(=O)C)C(F)(F)F
• Target: STAT,Interleukin,Glucocorticoid Receptor,JAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

STAT,Interleukin,Glucocorticoid Receptor,JAK