Glucagon Receptor Antagonist I

SKU: orb1693053

Description

This compound is a competitive glucagon receptor (GCGR) antagonist with an IC50 of 181 nM. It effectively inhibits glucagon-stimulated glycogenolysis in human hepatocytes and, in vivo, attenuates glucagon-induced hyperglycemia in mice at 50 mg/kg, making it a valuable tool for studying hepatic glucose metabolism and diabetes.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 438618-32-7
• MW: 346.53
• Formula: C₂₀H₃₀N₂OS
• SMILES: C(#N)C=1C2=C(SC1NC(C(CC)CC)=O)CC(C(CC)(C)C)CC2
• Target: AChR,Others,Glucagon Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

619101