Glucagon Receptor Antagonist I

SKU: orb1693053

Description

This compound is a competitive glucagon receptor (GCGR) antagonist with an IC50 of 181 nM. It effectively inhibits glucagon-stimulated glycogenolysis in human hepatocytes and, in vivo, attenuates glucagon-induced hyperglycemia in mice at 50 mg/kg, making it a valuable tool for studying hepatic glucose metabolism and diabetes.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	438618-32-7
MW	346.53
Formula	C₂₀H₃₀N₂OS
SMILES	C(#N)C=1C2=C(SC1NC(C(CC)CC)=O)CC(C(CC)(C)C)CC2
Target	AChR,Others,Glucagon Receptor

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

619101 ↗

Key Properties

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No computed properties available.

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