Glucagon (1-29), bovine, human, porcine hydrochloride

SKU: orb1308272

Description

Glucagon (1-29) hydrochloride is a synthetic peptide hormone, derived from bovine, human, or porcine sequences, that activates and phosphorylates HNF4α. It is widely used in metabolic research to study gluconeogenesis and glucose homeostasis in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 28270-04-4
• MW: 3519.21
• Purity: 98.03% (May vary between batches)
• Formula: C₁₅₃H₂₂₅N₄₃O₄₉S.ClH
• SMILES: Cl.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
• Target: Glucocorticoid Receptor,Glucagon Receptor
• Solubility: DMSO:250 mg/mL (71.04 mM);H2O:40 mg/mL (11.37 mM)

Bioactivity

• In Vivo:
  Glucagon (20 μg/kg) increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice .
• In Vitro:
  Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis. Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia. Glucagon (100 nM) increases the phosphorylation of HNF4α. Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes .

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

peptide, Glucagon Receptor, GlucagonReceptor, Glucagon hydrochloride, Glucagon , bovine, human, porcine Hydrochloride, Glucagon (1 29), bovine, human, porcine hydrochloride, Glucagon (1-29), bovine, human, porcine, Glucagon (129), bovine, human, porcine hydrochloride, gluconeogenesis, Glucocorticoid Receptor, glucocorticoid receptor, GlucocorticoidReceptor, HNF-4, HNF4α, pancreatic α

Compound Identifiers

PubChem CID

16186213