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GLS1 Inhibitor

SKU: orb1693054

Description

This small molecule GLS1 inhibitor exhibits potent activity against glutaminase 1 (IC50 = 0.021 µM). It demonstrates anti-proliferative effects in NCI-H1703 NSCLC cells in vitro (GI50 = 0.011 µM) and reduces tumor growth in a mouse xenograft model, modulating intratumoral glutamine and glutamate metabolism. This tool compound is used in cancer metabolism research, particularly for studying glutaminolysis in oncology models.

Research Area

Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

Key Properties

CAS Number1832646-52-2
MW411.48
FormulaC19H21N7O2S
SMILESN([C@H]1CN(CC1)C2=CC=CN=N2)C=3SC(NC([C@@H](OC)C4=CC=CC=C4)=O)=NN3
TargetOthers,Glutaminase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

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100 mg
$ 1,320.00
250 mg
$ 2,170.00
1 g
$ 4,010.00
DispatchUsually dispatched within 4-6 weeks
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