GLP-26

SKU: orb1309628

Description

GLP-26 is a potent HBV capsid assembly modulator (CAM) that inhibits HBV DNA replication with an IC50 of 3 nM in vitro. It disrupts pgRNA encapsidation, leading to nucleocapsid disassembly and a >90% reduction in cccDNA levels at 1 μM, making it a valuable tool for investigating HBV lifecycle and antiviral strategies.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 2133017-36-2
• MW: 373.35
• Purity: 98.62% (May vary between batches)
• Formula: C₁₉H₁₇F₂N₃O₃
• SMILES: Cc1c(C(=O)C(=O)NCC#C)c(C)n(C)c1C(=O)Nc1ccc(F)c(F)c1
• Target: HBV
• Solubility: DMSO:100 mg/mL (267.85 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.71 mM)

Bioactivity

• Target IC50:
  HBV:0.7 μM(EC50)|HBV:3 nM
• In Vitro:
  Administration of 0.7-1.7 μM GLP-26 for 3 days reduces secreted HBeAg in HepNTCP-DL cells transfected with HBV wild type with EC50 values of 0.7 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Hepatitis B virus, HBV, GLP26, GLP-26, GLP 26, inhibit

Compound Identifiers

PubChem CID

130408536