GLP-1R Antagonist 1

SKU: orb1707267

Description

GLP-1R Antagonist 1 is a brain-penetrant, orally bioavailable small molecule that non-competitively inhibits the glucagon-like peptide 1 receptor with an IC50 of 650 nM. It is a valuable research tool for investigating GLP-1R signaling in metabolic and neurological studies, suitable for both in vitro assays and in vivo models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 488097-06-9
• MW: 440.73
• Purity: 99.84% (May vary between batches)
• Formula: C₁₆H₁₁ClF₆N₄O₂
• SMILES: Cn1c2NC(=NC(c2c(=O)n(C)c1=O)(C(F)(F)F)C(F)(F)F)c1ccc(Cl)cc1
• Target: Glucagon Receptor
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (7.49 mM);DMSO:90 mg/mL (204.21 mM)

Bioactivity

• Target IC50:
  GLP1 receptor:650 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GLP-1R, GLP1R Antagonist 1, GLP-1R Antagonist 1, GLP 1R Antagonist 1, GLP-1, GlucagonReceptor, Glucagon Receptor

Compound Identifiers

PubChem CID

1941609