GLP-1(7-37) acetate(106612-94-6 free base)

SKU: orb1296636

Description

Glucagon-like peptide-1 (7-37) acetate is a bioactive incretin hormone analog that potentiates glucose-dependent insulin secretion. It is widely used in diabetes and metabolic research for in vitro receptor studies and in vivo investigations of pancreatic beta-cell function.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1450806-98-0
• MW: 3355.67
• Purity: 98.89% (May vary between batches)
• Formula: C₁₅₁H₂₂₈N₄₀O₄₇
• SMILES: O=C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCCNC(N)=N)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC6=CNC=N6)N
• Target: Glucagon Receptor
• Solubility: DMSO:6.71 mg/mL (2 mM);H2O:Soluble

Bioactivity

• In Vivo:
  GLP-1(7-37) (0.5, 5, or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of glucose-stimulated plasma insulin concentration and an increased glucose infusion rate in rats. Continuous infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 to 7 hours maintains a sustained increase in plasma insulin levels compared to vehicle-infused rats with glucose concentration held at 11 mM.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GLP 1 Acetate, GLP 1(7 37) acetate(106612 94 6 free base), GLP1 Acetate, GLP-1 Acetate, GLP-1 acetate(106612-94-6 free base), GLP-1(7-37) acetate, GLP1(737) acetate(106612946 free base), Glucagon Receptor, GlucagonReceptor, GCGR, inhibit, Inhibitor

Compound Identifiers

PubChem CID

16133830