Gliquidone

SKU: orb1310680

Description

Gliquidone is a potent second-generation sulfonylurea antidiabetic agent. It exhibits high affinity for the SUR1 receptor and functions as a PPARγ agonist. This compound is used in research to study insulin secretion mechanisms and metabolic pathways in both cellular and animal models of diabetes.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 33342-05-1
• MW: 527.63
• Purity: >99.99% (May vary between batches)
• Formula: C₂₇H₃₃N₃O₆S
• SMILES: CC1(C)C=2C(C(=O)N(CCC3=CC=C(S(NC(NC4CCCCC4)=O)(=O)=O)C=C3)C1=O)=CC(OC)=CC2
• Target: Others,COX,ROS,STAT,ERK,NF-κB,Interleukin,Potassium Channel
• Solubility: Ethanol:6 mg/mL (11.37 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (6.25 mM);DMSO:97 mg/mL (183.84 mM)

Bioactivity

• Target IC50:
  K+ channel:27.2 nM
• In Vitro:
  Intraventricular administration of 0.06–16 μg Gliquidone to each mouse counteracts the antinociceptive effects of tramadol, morphine, and methadone. A dose of 6 μg Gliquidone intraventricularly administered to each mouse inhibits the antinociceptive responses induced by subcutaneous injections of 0.125 mg/kg clonidine and 0.30 mg/kg chlorthalidone; however, a 3 μg dose is ineffective. In male Swiss albino mice, intraventricular injections of 0.1–1.0 μg Gliquidone dose-dependently suppress the antinociceptive effects of amitriptyline and chlorphenamine. In diabetic rats, a 10 mg/kg dose of Gliquidone significantly reduces blood pressure, diminishes non-enzymatic glycation, lowers total protein levels in the lens, and notably increases glutathione levels in the lens.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PotassiumChannel, Potassium Channel, inhibit, Gliquidone, Glurenorm, Inhibitor, AR-DF 26

Compound Identifiers

PubChem CID

91610