Gliotoxin

SKU: orb1684570

Description

Gliotoxin is a mycotoxin from Aspergillus fumigatus that acts as a Wnt signaling pathway inhibitor. It induces growth arrest and apoptosis in Wnt-mutant colorectal cancer cells via PKA activation, cAMP elevation, and suppression of NF-κB activity by stabilizing IκB. This molecule is a valuable tool for studying Wnt and NF-κB pathways in cancer research, both in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 67-99-2
• MW: 326.4
• Purity: >98%
• Formula: C₁₃H₁₄N₂O₄S₂
• SMILES: CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3
• Target: Nox (NADH/NADPH oxidase)
• Solubility: Soluble in DMSO (up to 15 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aspergillin

Compound Identifiers

PubChem CID

6223