Glimepiride

SKU: orb1310911

Description

Glimepiride (HOE-490) is a third-generation sulfonylurea antidiabetic agent with a prolonged duration of action. It is widely used in diabetes research to study insulin secretion mechanisms in pancreatic beta-cells, both in vitro and in established animal models of type 2 diabetes.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 93479-97-1
• MW: 490.62
• Purity: 97.84% (May vary between batches)
• Formula: C₂₄H₃₄N₄O₅S
• SMILES: C(NCCC1=CC=C(S(NC(N[C@H]2CC[C@H](C)CC2)=O)(=O)=O)C=C1)(=O)N3C(=O)C(CC)=C(C)C3
• Target: Beta Amyloid,Potassium Channel
• Solubility: 10% DMSO+90% Corn Oil:1.5 mg/mL (3.06 mM);DMSO:30 mg/mL (61.15 mM)

Bioactivity

• Target IC50:
  SUR1:3 nM|SUR2A:5.4 nM|SUR2B:7.3 nM
• In Vivo:
  Within diabetic rats, Glimepiride has been shown to decrease the incidence of sperm abnormalities, enhance sperm count, and bolster antioxidant capacity.
• In Vitro:
  In both normal and insulin-resistant adipocytes, as well as in myocytes, Glimepiride effectively stimulates glucose transport, and the synthesis of lipids and glycogen. In cardiomyocytes, Glimepiride (IC50=6.8 nM) inhibits the pinacidil-activated whole-cell K(ATP) current. Additionally, in HEK 293 cells, Glimepiride (IC50=6.2 nM) blocks the K(ATP) channels formed by the co-expression of Kir6.2/SUR2A subunits.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Glimepiride, Glimperide, HOE 490, HOE490, HOE-490, Potassium Channel, PotassiumChannel, SUR1, SUR2A, SUR2B

Compound Identifiers

PubChem CID

3476