GlcNAc-MurNAc

SKU: orb3135883

Description

GlcNAc-MurNAc is a disaccharide and mild TLR4 agonist with a Kd of 383 μM for mouse TLR4. It directly binds to TLR4, activating the downstream NF-κB and IRF pathways. Additionally, GlcNAc-MurNAc ameliorates dextran sulfate sodium salt (DSS)-induced colitis in mice through a TLR4-dependent mechanism, making it useful for inflammatory bowel disease research.

Key Properties

• CAS Number: 4500-70-3
• MW: 496.46
• Formula: C₁₉H₃₂N₂O₁₃
• SMILES: O([C@H]1[C@H](O[C@@H](C(O)=O)C)[C@@H](NC(C)=O)[C@H](O)O[C@@H]1CO)[C@H]2[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O2
• Target: TLR,Interleukin,TNF,NF-κB,Caspase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TLR,Interleukin,TNF,NF-κB,Caspase