Glaucine

SKU: orb1301260

Description

Glaucine is a natural alkaloid with demonstrated antitussive, antioxidant, and antiviral properties. Research indicates it exhibits anti-arthritic potential and modulates immune responses by enhancing IL-10 production. In vitro studies show it inhibits breast cancer cell migration and invasion via suppression of MMP-9 and the NF-κB pathway.

Research Area

Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 475-81-0
• MW: 355.43
• Purity: 99.56% (May vary between batches)
• Formula: C₂₁H₂₅NO₄
• SMILES: O(C)C1=C2C=3[C@](CC=4C2=CC(OC)=C(OC)C4)(N(C)CCC3C=C1OC)[H]
• Target: Influenza Virus,Adrenergic Receptor,Calcium Channel,NF-κB,Dopamine Receptor,PDE,MMP
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.63 mM);DMSO:30 mg/mL (84.4 mM)

Bioactivity

• Target IC50:
  PDE4:3.4 µM (Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Glaucine, Inhibitor, InfluenzaVirus, Influenza Virus, inhibit, NSC 34396, NSC34396, NSC-34396, O,O-Dimethylisoboldine, PDE4, Adrenergic Receptor, AdrenergicReceptor, alkaloid, anti-arthritic, antioxidative, anti-inflammatory, antitussive, antiviral, Ca channels, Ca2+, cAMP, Ca2+ channels, Calcium Channel, bronchodilation, DopamineReceptor, Dopamine, Dopamine Receptor, Beta Receptor, CalciumChannel, Phosphodiesterase (PDE), phosphodiesterase, α-adrenoceptor

Compound Identifiers

PubChem CID

16754