Glabrone

SKU: orb1297358

Description

Glabrone

Research Area

Infectious Disease & Virology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 60008-02-8
• MW: 336.34
• Purity: 99.55% (May vary between batches)
• Formula: C₂₀H₁₆O₅
• SMILES: CC1(C)Oc2ccc(c(O)c2C=C1)-c1coc2cc(O)ccc2c1=O
• Target: PPAR|||Influenza Virus
• Solubility: DMSO:50 mg/mL (148.66 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.97 mM)

Bioactivity

• In Vitro:
  On the basis of a shape-focused virtual screening, the roots of Glycyrrhiza glabra (licorice) were identified as plant species with an accumulation of constituents that show 3D similarities to known influenza NA inhibitors (NAIs). Phytochemical investigation revealed 12 constituents identified as (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2-propen-1-one (1), 3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-ol (2), biochanin B (3), glabrol (4), Glabrone (5), hispaglabridin B (6), licoflavone B (7), licorice glycoside B (8), licorice glycoside E (9), liquiritigenin (10), liquiritin (11), and prunin (12). Eleven of these constituents showed significant influenza virus NA inhibition in a chemiluminescence (CL)-based assay. Additional tests, including (i) a cell-based cytopathic effect inhibition assay (general antiviral activity), (ii) the evaluation of cytotoxicity, (iii) the inhibition of the NA of Clostridium perfringens (CL- and fluorescence (FL)-based assay), and (iv) the determination of self-fluorescence and quenching, provided further perspective on their anti-influenza virus potential, revealing possible assay interference problems and false-positive results
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, InfluenzaVirus, Influenza virus, Influenza Virus, Glabrone, Inhibitor, Peroxisome proliferator-activated receptors, PPAR

Compound Identifiers

PubChem CID

5317652