Glabrol

SKU: orb1297359

Description

5-Methylcytosine is an epigenetic DNA modification catalyzed by DNA methyltransferases. This small molecule is widely used in epigenetics research to study gene regulation, genomic imprinting, and cellular differentiation in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 59870-65-4
• MW: 392.49
• Purity: 99.72% (May vary between batches)
• Formula: C₂₅H₂₈O₄
• SMILES: CC(C)=CCc1cc(ccc1O)[C@@H]1CC(=O)c2ccc(O)c(CC=C(C)C)c2O1
• Target: Acyltransferase|||NF-κB|||Cytochromes P450|||NO Synthase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.1 mM);DMSO:65 mg/mL (165.61 mM)

Bioactivity

• Target IC50:
  ACAT (rat):24.6 μM (IC50)
• In Vitro:
  Based on the bioactivities of licorice, these compounds were screened using cell- or enzyme-based bioassay methods. A total of 11 compounds exhibited potent cytotoxic activities against three human cancer cell lines (HepG2, SW480 and MCF7), while showed little toxicity on human normal cell lines LO2 and HEK293T
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Diglyceride acyltransferase, Diacylglycerol acyltransferase, Acyltransferase, acyl-CoA:cholesterol acyltransferase, NF-kB, NFkB, P450, NO Synthase, NFκB, NF-κB, inhibit, Inhibitor, NOSynthase, mono- acylglycerol acyltransferase, Glabrol

Compound Identifiers

PubChem CID

11596309