Givinostat hydrochloride monohydrate

SKU: orb1300909

Description

Givinostat hydrochloride monohydrate (ITF2357) is a histone deacetylase (HDAC) inhibitor. It is used in biochemical and cellular research to study epigenetic regulation and has been investigated in preclinical models for conditions such as Duchenne muscular dystrophy and inflammatory diseases.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 732302-99-7
• MW: 475.97
• Purity: 98.09% (May vary between batches)
• Formula: C₂₄H₂₇N₃O₄·HCl·H₂O
• SMILES: O.Cl.CCN(CC)Cc1ccc2cc(COC(=O)Nc3ccc(cc3)C(=O)NO)ccc2c1
• Target: HDAC
• Solubility: DMSO:88 mg/mL (184.89 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.93 mM);Ethanol:1 mg/mL (2.1 mM)

Bioactivity

• Target IC50:
  HDAC8 (human):854 nM|HD1-A:16 nM|HDAC7 (human):524 nM|HDAC5 (human):532 nM|HDAC11 (human):292 nM|HDAC2 (human):325 nM|HDAC4 (human):1059 nM|HD2:10 nM|HDAC9 (human):541 nM|HDAC3 (human):157 nM|HDAC6 (human):315 nM|HD1-B:7.5 nM|HDAC1 (human):198 nM|HDAC10 (human):340 nM
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ITF-2357 hydrochloride monohydrate, Gavinostat hydrochloride monohydrate, Gavinostat Hydrochloride, HDAC, HD2, HD1-B, HD1-A

Compound Identifiers

PubChem CID

9804991