Gitogenin

SKU: orb1222136

Description

Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. Gitogenin and (25S)-5α-furastan-3β, 22, 26-triol are the inhibitors of enzyme α-glucosidase with IC50 values of 37.2±0.18 and 33.5±0.22 uM, respectively.3. Gitogenin shows moderate stimulation of release activity on growth hormone from rat pituitary cells.

Key Properties

• CAS Number: 511-96-6
• MW: 432.64
• Purity: >98% (HPLC)
• Formula: C₂₇H₄₄O₄
• SMILES: CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CC(C(C6)O)O)C)C)C)OC1
• Target: UGT1A4
• Solubility: In Vitro: DMSO : 1.85 mg/mL (4.28 mM)

Bioactivity

• In Vivo:
  Stimulation of growth hormone release is investigated on rat pituitary cells in vitro. Gitogenin (20 μg/mL) showsrat growth-hormone (rGH) release stimulating activities (26.1 ng/mL).
• In Vitro:
  When tamoxifen is used as the substrate metabolized by UGT1A4 in HLMs, Gitogenin exhibits potent inhibition of tamoxifen, with an IC50 value of 6.13 μM. Similarly, for midazolam as the substrate of UGT1A4, the IC50 value is 5.7 μM. In addition, when olanzapine is used as a substrate of UGT1A4, the IC50 value is determined as 6.0 μM. Finally, we also evaluats Gitogenin for asenapine glucuronidation mediated by UGT1A4, and similar inhibition effect is observed, with an IC50 value of 22.0 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AI3-62266, Digin, Gitogenin

Quick Database Links

Gene Symbol

UGT1A4