GIT1-IN-1

SKU: orb3210581

Description

GIT1-IN-1 is an inhibitor of ARF GTPase-activating protein 1 (GIT1), with a KD value of 6.2 μM. It induces apoptosis (cell death) in liver cancer and colon cancer cells, halts the cell cycle in the G2/M phase, and suppresses cell proliferation, colony formation, and migration. Furthermore, GIT1-IN-1 can inhibit the activity of MEK and ERK in liver and colon cancer cells, reduce cyclin D1 expression, and stabilize cyclin B1 protein. This compound is applicable for research in liver and colon cancer.

Key Properties

• CAS Number: 844464-54-6
• MW: 424.47
• Formula: C₂₁H₂₀N₄O₄S
• SMILES: O=C1C=2SC3=NC4=C(C=C3C2N=CN1CC(=O)NCC=5OC=CC5)COC(C)(C)C4
• Target: MEK,Ras,ERK,Apoptosis,CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MEK,Ras,ERK,Apoptosis,CDK