Ginsenoside Rg6

SKU: orb1684960

Description

Ginsenoside Rg6 is a bioactive compound that suppresses proliferation and promotes apoptosis in human lymphoma JK cells. This small molecule is utilized in cancer research, particularly for studying its antitumor mechanisms in vitro, with investigations extending to its effects in various other cancer cell lines.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 147419-93-0
• MW: 767
• Purity: ≥98% (May vary between batches)
• Formula: C₄₂H₇₀O₁₂
• SMILES: [H][C@@]12[C@H](CC[C@@]1(C)[C@]1(C)C[C@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O[C@]3([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)[C@@]1([H])C[C@H]2O)C(=C)CCC=C(C)C
• Target: Apoptosis,NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (5.22 mM);DMSO:100 mg/mL (130.38 mM)

Bioactivity

• Target IC50:
  NF-κB:29.34 μM|NF-κB:25.12 μM (in SK-Hep1 cell)
• In Vitro:
  Ginsenoside Rg6 may inhibit the proliferation and induce apoptosis of human lymphoma JK cells through mitochondrial dysfunction and increased Bax expression and decreased Bcl-2 expression. In addition, ginsenoside Rg6 can also inhibit the transcriptional activity of NF-κB induced by TNF-α in SK-Hep1 cells with IC50 of 25uM.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NF-κB, NFκB, NF-kB, NFkB, Nuclear factor-kappaB, Nuclear factor-κB, Inhibitor, inhibit, Ginsenoside Rg 6, Ginsenoside Rg6, Ginsenoside Rg-6, Apoptosis, Bcl-2

Compound Identifiers

PubChem CID

91895489