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GGTI298

SKU: orb1709611

Description

GGTI298 is a selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I). It potently inhibits Rap1A geranylgeranylation (IC50 ~3 µM in vivo) with minimal effect on Ha-Ras farnesylation (IC50 >20 µM). This selectivity makes it a valuable research tool for studying geranylgeranylated proteins in cancer, cardiovascular, and inflammatory disease research.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number180977-44-0
MW479.63
FormulaC27H33N3O3S
SMILESC(N[C@H](C(OC)=O)CC(C)C)(=O)C1=C(C=C(NC[C@H](CS)N)C=C1)C=2C3=C(C=CC2)C=CC=C3
TargetApoptosis,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information