GF109203X

SKU: orb1226533

Description

GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.

Key Properties

• CAS Number: 133052-90-1
• MW: 412.48
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₄N₄O₂
• SMILES: O=C(C(C1=CN(CCCN(C)C)C2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O.
• Target: PDGFR
• Solubility: DMSO:82 mg/mL (198.79 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)

Bioactivity

• In Vivo:
  Animal model: Quinpirole-treated shrews. Dosage: 0-20 mg/kg. Administration: i.p. Result: Reduced the mean frequency of Quinpirole-induced vomiting. Blocked Quinpirole-mediated ERK1/2 phosphorylation in shrew brainstems.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BIM I | GF 109203X | G? 6850

Quick Database Links

Gene Symbol

PDGFR