Geraniin

SKU: orb1300171

Description

Geraniin is a natural polyphenol with research applications in bone biology and oncology. It demonstrates protective effects against osteoporosis and osteolysis in rodent models, while also exhibiting cytotoxic activity against cancer cells in vitro and in vivo. Furthermore, it shows antioxidant and radioprotective properties through mechanisms involving Nrf2 pathway activation and DNA damage regulation.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 60976-49-0
• MW: 952.64
• Purity: 99.92% (May vary between batches)
• Formula: C₄₁H₂₈O₂₇
• SMILES: Oc1cc(cc(O)c1O)C(=O)O[C@@H]1O[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)cc3C(=O)O[C@@H]3[C@H]2OC(=O)C2=CC(=O)C4(O)Oc5c(O)c(O)cc(c5C2C4(O)O)C(=O)O[C@H]13
• Target: TNF,Antioxidant
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (3.46 mM);Pyridine, Methanol, etc.:Soluble;Ethanol:Soluble;DMSO:247.5 mg/mL (259.8 mM)

Bioactivity

• Target IC50:
  TNF-α:43 μM.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antioxidant, Inhibitor, Geraniin, inhibit, Tumor Necrosis Factor Receptor, TNF Receptor, TNFR, TNF-α

Compound Identifiers

PubChem CID

137699315