Gentianine

SKU: orb1684578

Description

Gentianine, a Swertiamarin-derived small molecule, exhibits a broad pharmacological profile including anti-diabetic, anti-inflammatory, and antihypertensive activities in preclinical studies. It is utilized in research areas such as metabolic and cardiovascular disease, with applications in both in vitro assays and in vivo animal models.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 439-89-4
• MW: 175.18
• Formula: C₁₀H₉NO₂
• SMILES: C=CC1=CN=CC2=C1CCOC2=O
• Target: transporter|||PPAR|||TNF

Bioactivity

• In Vivo:
  Effect of Gentianine on tMCAO mouse demonstrated that Gentianine significantly ameliorated tMCAO induced ischemic injury by decreasing brain infarct volume and increasing the neurological score and upper limb muscle strength. Meanwhile, Gentianine significantly decreased the release of serum inflammatory cytokines. Machine learning enables that Gentianine might had anti-ischemic stroke effect through the TLR4/NF-κB signaling pathway.
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• In Vitro:
  Gentianine significantly decreased TLR4, MyD88 and NF-κB expression, as well as NO production and inflammatory cytokines release. Gentianine co-treatment with TLR4 inhibitor, further decreased TLR4, MyD88 and NF-κB expression, NO production, as well as the inflammatory cytokines. Taken together, Gentianine could be used as a potential anti-ischemic stroke agent by suppressing inflammatory responses via TLR4/NF-κB signaling pathway. Treatment with Gentianine significantly increased adipogenesis, which was associated with a significant increase in the mRNA expression of PPAR-γ, GLUT-4 and adiponectin
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TNF-α, PPAR, GLUT, Gentianine

Compound Identifiers

PubChem CID

354616