Gemigliptin Tartrate(911637-19-9 free base)

SKU: orb1685500

Description

Gemigliptin Tartrate (LC15-0444 tartrate) is a potent, selective, and competitive DPP-4 inhibitor with an IC₅₀ of 10.3 nM. It is utilized in diabetes research for its anti-hyperglycemic and anti-glycation effects, as demonstrated in both in vitro enzymatic assays and in vivo metabolic disease models.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 1374639-74-3
• MW: 639.45
• Purity: >99.99% (May vary between batches)
• Formula: C₂₂H₂₅F₈N₅O₈
• SMILES: O[C@H]([C@@H](O)C(O)=O)C(O)=O.N[C@H](CN1CC(F)(F)CCC1=O)CC(=O)N1CCc2c(C1)nc(nc2C(F)(F)F)C(F)(F)F
• Target: DPP-4,Proteasome
• Solubility: DMSO:90 mg/mL (140.75 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.16 mM)

Bioactivity

• Target IC50:
  DPP4 (human recombinant):10.3 nM
• In Vivo:
  Gemigliptin tartrate inhibits AGEs formation and AGE cross-links in vivo. Gemigliptin tartrate dose-dependently inhibits plasma DPP-4 activity in rats, dogs, and monkeys.
• In Vitro:
  Gemigliptin tartrate inhibits the formation of AGE-BSA with IC50 of 11.69 mM. Gemigliptin tartrate suppresses the cross-linking of preformed AGE-BSA with rat tail tendon collagen with an IC50 of 1.39 mM. Gemigliptin tartrate is a competitive DPP-4 inhibitor with a Ki of 7.25 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Gemigliptin, Gemigliptin Tartrate(911637 19 9 free base), Gemigliptin Tartrate(911637199 free base), Gemigliptin Tartrate(911637-19-9 free base), LC15-0444, LC15-0444 tartrate, LC15-0444 Tartrate, mellitus, glycation, end, advanced, AGE, DPP4, DPP-4, DPP, diabetes, Dipeptidyl Peptidase, dipeptidyl, type, peptidase-4, products

Compound Identifiers

PubChem CID

60199080