Gemcabene

SKU: orb1309634

Description

Gemcabene (PD-72953) is a small molecule lipid-lowering agent with anti-inflammatory properties. It modulates lipid profiles by lowering LDL-C and triglycerides while raising HDL-C, and reduces inflammatory markers like C-reactive protein. Research applications include in vitro mechanistic studies and in vivo models of dyslipidemia and inflammation.

Research Area

Metabolism Research

Key Properties

• CAS Number: 183293-82-5
• MW: 302.41
• Purity: ≥98% (May vary between batches)
• Formula: C₁₆H₃₀O₅
• SMILES: CC(C)(CCCCOCCCCC(C)(C)C(O)=O)C(O)=O
• Target: Others,LDLR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.91 mM);DMSO:95 mg/mL (314.14 mM)

Bioactivity

• In Vitro:
  Gemcabene significantly downregulates hepatic mRNA markers of inflammation including TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB, lipogenesis, fibrosis including TIMP-1 and MMP-2, and lipid modulation including ApoC-III, ACC1, ADH-4 and Sulf-2.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Gemcabene, Inhibitor, inhibit, PD72953, PD-72953, PD 72953

Compound Identifiers

PubChem CID

157692