Gedatolisib

SKU: orb1226823

Description

A highly potent, selective, dual PI3K/mTOR inhibitor with IC50 of 0.4/6/8/6/1.6 nM for PI3Kα/β/γ/δ/mTOR, respectively; also potently inhibits PI3Kα mutant H1047R and E545K with IC50 of 0.6 and 0.6 nM; prevents the pAkt at Thr 308 with IC50 of 8 nM, and suppresses pAkt S473 with IC50 of <10 nM in cells; demonstrates antitumor efficacy in both subcutaneous and orthotopic xenograft tumor models.Blood Cancer Phase 3 Clinical.

Key Properties

• CAS Number: 1197160-78-3
• MW: 615.72
• Purity: >98% (HPLC)
• Formula: C₃₂H₄₁N₉O₄
• SMILES: O=C(NC1=CC=C(C2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C=C1)NC5=CC=C(C(N6CCC(N(C)C)CC6)=O)C=C5
• Target: PI3K
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PF-05212384 | PKI-587

Quick Database Links

Gene Symbol

PI3K