GeA-69

SKU: orb1301822

Description

GeA-69 is a selective, allosteric inhibitor targeting the PARP14 macrodomain 2 (MD2), with a binding affinity (Kd) of 0.86 µM. This small molecule is a valuable research tool for investigating PARP14's role in cancer, inflammation, and viral infection through in vitro biochemical and cellular studies.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2143475-98-1
• MW: 300.35
• Purity: 99.75% (May vary between batches)
• Formula: C₂₀H₁₆N₂O
• SMILES: CC(=O)Nc1ccccc1-c1cccc2c3ccccc3[nH]c12
• Target: PARP
• Solubility: DMSO:120 mg/mL (399.53 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.32 mM)

Bioactivity

• Target IC50:
  PARP14:0.86 μM (Kd, in ITC assays)
• In Vitro:
  The macrodomain recruitment was significantly decreased in cells pre-treated with 50 μM GeA-69 and completely prevented in cells exposed to 250 μM GeA-69.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cytotoxicity, DNA damage repair mechanism, cell permeable, HeLa, HEK293, intact cell, Inhibitor, GeA 69, GeA69, GeA-69, inhibit, poly ADP ribose polymerase, PARP, PARP14, U-2 OS

Compound Identifiers

PubChem CID

135397654