GDP366

SKU: orb1709622

Description

GDP366 is a dual survivin and Op18 inhibitor that triggers growth arrest, senescence, and mitotic catastrophe in cancer cells. This small molecule is a useful research tool for studying cell cycle disruption and apoptosis mechanisms in both in vitro and in vivo oncology models.

Research Area

Cell Biology

Key Properties

• CAS Number: 501698-03-9
• MW: 375.45
• Purity: 99.84% (May vary between batches)
• Formula: C₂₀H₁₇N₅OS
• SMILES: Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1
• Target: Survivin
• Solubility: DMSO:60 mg/mL (159.81 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.33 mM)

Bioactivity

• In Vitro:
  GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, GDP-366, GDP 366, GDP366, inhibit, Survivin

Compound Identifiers

PubChem CID

6539985