GDC0575 monohydrochloride

SKU: orb1305087

Description

GDC-0575 monohydrochloride (ARRY-575) is a highly potent and selective Chk1 inhibitor (IC50 = 1.2 nM). It disrupts Chk1-mediated cell cycle checkpoints, forcing DNA-damaged cells into mitosis. This mechanism is applied in preclinical cancer research, particularly in combination with DNA-damaging agents, to study chemosensitization in vitro and in vivo models.

Research Area

Cell Biology

Key Properties

• CAS Number: 1196504-54-7
• MW: 414.73
• Purity: 97.85%
• Formula: C₁₆H₂₁BrClN₅O
• SMILES: O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32.[H]Cl
• Target: Chk
• Solubility: DMSO:60 mg/mL (144.67 mM)

Bioactivity

• Target IC50:
  Chk1:1.2 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chk1, ARRY575, ARRY-575, ARRY 575, GDC 0575, GDC 0575 Monohydrochloride, GDC0575, GDC-0575, GDC0575 Monohydrochloride, GDC0575 monohydrochloride, GDC-0575 Monohydrochloride, GDC-0575 monohydrochloride

Compound Identifiers

PubChem CID

67045163