GDC-1971

SKU: orb3054185

Description

Migoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor.

Key Properties

• CAS Number: 2377352-49-1
• MW: 454.53
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₆N₈O
• Solubility: DMSO : 100 mg/mL (220.01 mM; ultraphonic; )

Bioactivity

• In Vivo:
  Animal model: RIT1 xenograft mouse models. Dosage: 60 mg/kg. Administration: po for 28 days. Result: Inhibited tumor growth.
• In Vitro:
  Western blot analysis. Cell line: RIT1. Concentration: 0-10 μM. Incubation time: 24 h. Result: Inhibited the p-ERK1/2.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only