GDC-0879

SKU: orb1223694

Description

A potent and selective B-Raf kinase inhibitor with IC50 of 0.13 nM against purified B-Raf V600E and a cellular pERK IC50 of 63 nM in the MALME-3M cell line; shows expected activity only against C-Raf against a panel of 140 kinases at 1 uM; shows comparable potency in A375 melanoma and Colo205 colorectal carcinoma cell lines with IC50 of 59 nM and 29 nM for pMEK1 inhibition respectively; shows tumor growth inhibition in A375 xenografts; orally active.Skin Cancer Preclinical.

Key Properties

• CAS Number: 905281-76-7
• MW: 334.3718
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈N₄O₂
• SMILES: OCCN1N=C(C2=CC=NC=C2)C(C3=CC4=C(/C(CC4)=N/O)C=C3)=C1
• Target: Raf
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GDC0879 | GDC 0879

Quick Database Links

Gene Symbol

Raf