GDC-0134

SKU: orb2815663

Description

GDC-0134 is a brain-penetrant, small-molecule inhibitor of dual leucine zipper kinase (DLK) that blocks downstream JNK activation to prevent neuronal degeneration. It is utilized in preclinical research for neurodegenerative diseases like ALS, with studies demonstrating neuroprotective effects in both cellular and animal models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1637394-01-4
• MW: 440.4
• Formula: C₁₉H₂₀F₄N₆O₂
• SMILES: FC1(F)CN(C=2N=C(C=C(N2)C=3C=C(OC(F)F)C(N)=NC3)N4[C@]5(C[C@@](C4)(OC5)[H])[H])CC1
• Target: JNK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

86298636