GDC-0084

SKU: orb1226401

Description

A potent, selective, brain penetrant dual inhibitor of class I PI3Ks and mTOR with Ki of 2/46/3/10/70 nM for PI3Kα/β/δ/γ/mTOR, respectively; highly selective against a panel of 229 kinases (IC50>1 uM); shows antiproliferative (EC50 =0.3-1.1 uM) in 5 GBM cell lines; significantly and dose-dependently inhibits tumor growth in a subcutaneous U87 tumor xenograft model of glioblastoma in mice.Brain Cancer Phase 2 Discontinued.

Key Properties

• CAS Number: 1382979-44-3
• MW: 382.4197
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₂N₈O₂
• SMILES: NC1=NC=C(C2=NC(N3CCOCC3)=C4N=C(C(C)(C)OCC5)N5C4=N2)C=N1
• Target: PI3K
• Solubility: DMSO: 6 mg/mL (Need ultrasonic)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RG-7666

Quick Database Links

Gene Symbol

PI3K