GCN2-IN-1

SKU: orb1309638

Description

GCN2-IN-1 (A-92) is a potent and selective inhibitor of the GCN2 kinase, a key regulator of the integrated stress response. It serves as a valuable research tool for investigating cancer biology and has demonstrated utility in both in vitro cellular assays and in vivo tumor model studies for potential chemotherapeutic development.

Research Area

Cell Biology

Key Properties

• CAS Number: 1448693-69-3
• MW: 402.41
• Purity: 99.64% (May vary between batches)
• Formula: C₁₉H₁₈N₁₀O
• SMILES: C1CC(CCO1)n1cc(Nc2ncc3nnn(-c4ccc5cn[nH]c5c4)c3n2)cn1
• Target: PERK,Others
• Solubility: DMSO:9.6 mg/mL (23.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.97 mM)

Bioactivity

• Target IC50:
  GCN2:<0.3 μM
• In Vitro:
  GCN2-IN-1 inhibits GCN2 with an IC50 of <0.3 μM in the enzyme assay and an IC50 of 0.3-3 μM in the cell assay.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A 92, A92, A-92, Inhibitor, inhibit, GCN2IN1, GCN2-IN-1, GCN2, GCN2 IN 1, Eukaryotic Initiation Factor (eIF)

Compound Identifiers

PubChem CID

89720372