GCN2 activator-1

SKU: orb3136190

Description

GCN2 activator-1 (Compound 20) is a GCN2 activator that binds to the ATP pocket of GCN2 and activates it in a GCN1-independent manner. It can stimulate the integrated stress response (ISR) in cells and inhibits PKR with an IC50 of 3.75 µM. GCN2 activator-1 is utilized for research on pulmonary veno-occlusive disease (PVOD).

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 315705-10-3
• MW: 290.37
• Formula: C₁₁H₁₀N₆S₂
• SMILES: N=1C=CC=NC1NC2=NC(=CS2)C=3SC(=NC3C)N
• Target: PERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PERK