GC7 Sulfate

SKU: orb1709631

Description

GC7 Sulfate is a selective deoxyhypusine synthase (DHS) inhibitor that blocks the hypusination and activation of its sole substrate, eIF5A2. This compound is a valuable research tool for studying eukaryotic translation, cell proliferation, and cancer mechanisms in both cellular and animal models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 150417-90-6
• MW: 270.35
• Purity: 98.07% (May vary between batches)
• Formula: C₈H₂₂N₄O₄S
• SMILES: O=S(=O)(O)O.N=C(N)NCCCCCCCN
• Target: Autophagy,DNA/RNA Synthesis
• Solubility: H2O:90 mg/mL (332.9 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  S1P1:10 nM(ki)
• In Vitro:
  Cell cycle analysis show that GC7 Sulfate reduces the CHO-K1 cell population in the G1-phase of the cell cycle by 42% and increases the number of cells in the S-phase by 44%. Furthermore, GC7 Sulfate inhibited the growth of H9 cells in a concentration-dependent manner. While 1 μM GC7 Sulfate had no significant effect on H9 cell proliferation, inhibition of growth became evident with 3 μM GC7 Sulfate. At 10 μM GC7 Sulfate, H9 cell growth was completely blocked within 1 or 2 days after the addition of the drug.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DHPS, GC7 Sulfate, GC-7 Sulfate, GC 7 Sulfate

Compound Identifiers

PubChem CID

131842088