GBR 12783 dihydrochloride

SKU: orb1706184

Description

GBR 12783 dihydrochloride is a potent and selective dopamine transporter (DAT) inhibitor, demonstrating nanomolar IC₅₀ values in rodent striatal synaptosome assays. It has been shown to enhance memory performance and elevate hippocampal acetylcholine release in rat models, supporting its application in neuroscience research related to dopaminergic signaling and cognition.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 67469-75-4
• MW: 485.49
• Purity: 98.08%
• Formula: C₂₈H₃₄Cl₂N₂O
• SMILES: N1(CCN(CC1)CC=CC2=CC=CC=C2)CCOC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl
• Target: Dopamine Receptor,Others
• Solubility: DMSO:45 mg/mL (92.69 mM)

Bioactivity

• In Vivo:
  GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GBR-12783, GBR12783 2HCl, GBR12783 Dihydrochloride, GBR-12783 Dihydrochloride, GBR 12783, GBR 12783 Dihydrochloride, GBR12783

Compound Identifiers

PubChem CID

53422048