GB1107

SKU: orb1308279

Description

GB1107 is a potent and selective small molecule inhibitor of Galectin-3, exhibiting a dissociation constant (Kd) of 37 nM. It is a valuable research tool for studying galectin-3's role in cancer, fibrosis, and inflammation in both cellular and animal models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 1978336-61-6
• MW: 522.32
• Purity: >99.99% (May vary between batches)
• Formula: C₂₀H₁₆Cl₂F₃N₃O₄S
• SMILES: OC[C@H]1O[C@H](Sc2ccc(Cl)c(Cl)c2)[C@H](O)[C@H]([C@H]1O)n1cc(nn1)-c1cc(F)c(F)c(F)c1
• Target: Galectin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.83 mM);DMSO:150 mg/mL (287.18 mM)

Bioactivity

• Target IC50:
  GAL3 (human):（kd）37 nM
• In Vivo:
  In CD-1 nude female mice received 3x106 human lung adenocarcinoma cells (A549), GB1107 (10 mg/kg, p.o.) significantly reduces tumor growth and final tumor weights.
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• In Vitro:
  GB1107 (0-1 μM) increases CD8+ T cell infiltration and tumor M1 macrophage polarization. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase the expression of cytotoxic and apoptotic effector molecules including perforin-1, Fas ligand, IFN-γ, granzyme B, and cleaved caspase-3.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(3,4,5-trifluorophenyl)triazol-1-yl]oxane-3,5-diol, human Gal-3, GB1107, GB-1107, GB 1107, Galectin-3

Compound Identifiers

PubChem CID

122443390