Gastrodin

SKU: orb1304755

Description

Gastrodin

Research Area

Cell Biology

Key Properties

• CAS Number: 62499-27-8
• MW: 286.28
• Purity: 100.00% (May vary between batches)
• Formula: C₁₃H₁₈O₇
• SMILES: O([C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C2=CC=C(CO)C=C2
• Target: Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.99 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:252.5 mg/mL (882 mM)

Bioactivity

• In Vivo:
  In microglial cells stimulated by lipopolysaccharide, Gastrodin at concentrations of 30, 40, and 60 mM inhibits the NF-κB signaling pathway and phosphorylation of MAPKs, significantly reducing the levels of neurotoxic inflammatory mediators and cytokines. Furthermore, in H9c2 cardiomyocytes, Gastrodin upregulates the PI3-K/Akt signaling pathway, consequently inhibiting the activation of NF-κB and MAPKs.
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• In Vitro:
  In mice, the LD50 of Gastrodin is greater than 1000 mg/kg (i.v.). In rats, Gastrodin at a dose of 5 mg/kg is effective in alleviating memory deficits induced by cycloheximide and apomorphine but is ineffective against scopolamine-induced acquisition impairments. Therefore, Gastrodin enhances memory consolidation and retrieval but does not facilitate memory acquisition.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Gastrodine, Gastrodin

Compound Identifiers

PubChem CID

115067