Gartanin

SKU: orb1297363

Description

Gartanin is a small molecule that enhances androgen receptor degradation. It exhibits neuroprotective properties in models of glutamate-induced oxidative stress, mediated in part through the upregulation of HO-1 and activation of AMPK/SIRT1/PGC-1α pathways. This compound is used in research fields including neurodegeneration, oncology, and oxidative stress, with applications in both in vitro and in vivo experimental systems.

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 33390-42-0
• MW: 396.43
• Purity: 99.85% (May vary between batches)
• Formula: C₂₃H₂₄O₆
• SMILES: CC(C)=CCc1c(O)c(CC=C(C)C)c2oc3c(O)ccc(O)c3c(=O)c2c1O
• Target: Caspase,Autophagy,JNK,Bcl-2 Family,Antifungal
• Solubility: DMSO:50 mg/mL (126.13 mM)

Bioactivity

• In Vitro:
  The interaction of Gartanin with the ligand-binding domain was characterized using a fluorescence polarization cell-free assay and cell-based FRET assay. Western blot analysis identified modulation of ER stress markers (BiP, PERK, IRE1, and CHOP) along with androgen receptor degradation. A computation simulation was performed to identify possible orientations of Gartanin with the ligand-binding domain. Utilizing a cell-free and cell-based FRET assays Gartanin was found to interact with the ligand-binding domain through a solely antagonist interaction. Interestingly, inhibition of CHOP, a critical component of the ER stress pathway, was observed to stabilize AR
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JNK, inhibit, Gartanin, Inhibitor, Fungal, Autophagy, Caspase, Bcl-2

Compound Identifiers

PubChem CID

5281633