Gartanin

SKU: orb1297363

Description

Gartanin

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 33390-42-0
• MW: 396.43
• Purity: 99.85%
• Formula: C₂₃H₂₄O₆
• SMILES: CC(C)=CCc1c(O)c(CC=C(C)C)c2oc3c(O)ccc(O)c3c(=O)c2c1O
• Target: JNK,Bcl-2 Family,Antifungal,Caspase,Autophagy

Bioactivity

• In Vitro:
  The interaction of Gartanin with the ligand-binding domain was characterized using a fluorescence polarization cell-free assay and cell-based FRET assay. Western blot analysis identified modulation of ER stress markers (BiP, PERK, IRE1, and CHOP) along with androgen receptor degradation. A computation simulation was performed to identify possible orientations of Gartanin with the ligand-binding domain. Utilizing a cell-free and cell-based FRET assays Gartanin was found to interact with the ligand-binding domain through a solely antagonist interaction. Interestingly, inhibition of CHOP, a critical component of the ER stress pathway, was observed to stabilize AR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JNK, inhibit, Gartanin, Inhibitor, Fungal, Autophagy, Caspase, Bcl-2

Compound Identifiers

PubChem CID

5281633