Gardenin A

SKU: orb1682517

Description

Gardenin A demonstrates neurotrophic activity through MAPK/ERK, PKC, and PKA pathway activation. This small molecule has shown promising antidepressant, anxiolytic, and anticonvulsant properties in preclinical research, supporting its investigation in neuroscience and neuropharmacology studies.

Research Area

Epigenetics & Chromatin, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 21187-73-5
• MW: 418.39
• Purity: 99.98% (May vary between batches)
• Formula: C₂₁H₂₂O₉
• SMILES: O(C)C1=C2C(=C(O)C(OC)=C1OC)C(=O)C=C(O2)C3=CC(OC)=C(OC)C(OC)=C3
• Target: PKA,MAPK,ERK,PAK,LDL,PKC
• Solubility: DMSO:21.6 mg/mL (51.63 mM)

Bioactivity

• Target IC50:
  colon cancer cells (human):> 100 μM|HL-60 cells:> 100 μM
• In Vitro:
  Oral administratGardenin A (25 mg/kg) shows sedative effects and increases the duration of sleep without altering sleep onset.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PKA, PKC, Gardenin A, LDL, MAPK, ERK

Compound Identifiers

PubChem CID

261859