Garcinone D

SKU: orb1297365

Description

Garcinone D

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 107390-08-9
• MW: 428.47
• Purity: 99.96%
• Formula: C₂₄H₂₈O₇
• SMILES: COc1c(O)cc2oc3cc(O)c(CC=C(C)C)c(O)c3c(=O)c2c1CCC(C)(C)O
• Target: STAT,Nrf2,Reactive Oxygen Species
• Solubility: DMSO:50 mg/mL (116.69 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.67 mM)

Bioactivity

• In Vitro:
  Meanwhile the root bark o the plant furnished Six xanthones, namely alpha-mangostin (2), beta-mangostin (3), gamma-mangostin (4), Garcinone D (5), mangostanol (6), and gartanin (7) the hexane and chloroform extracts o the root bark of G. mangostana as well a the hexane extract o the stem bark were found to be active agains the CEM-SS cell line. gamma-Mangostin (4) showed good activity with a very low IC(50) value of 4.7 microg/ml, while alpha-mangostin (2), mangostanol (6), and Garcinone D (5) showed significant activities with IC(50) Values of 5.5, 9.6, and 3.2 microg/ml, respectivel

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Garcinone D, inhibit, Keap1-Nrf2, NF-κB, p65, ReactiveOxygenSpecies, Reactive Oxygen Species, STAT3, STAT

Compound Identifiers

PubChem CID

5495926