Garcinone D

SKU: orb1297365

Description

Garcinone D is a bioactive small molecule with cytotoxic activity against the CEM-SS cell line (IC50 = 3.2 µg/ml) and inhibits both microsomal aromatase and NF-κB p65 activation (IC50 = 3.2 µM). This compound is a useful research tool for studying cancer biology and inflammatory pathways in vitro.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 107390-08-9
• MW: 428.47
• Purity: 99.96% (May vary between batches)
• Formula: C₂₄H₂₈O₇
• SMILES: COc1c(O)cc2oc3cc(O)c(CC=C(C)C)c(O)c3c(=O)c2c1CCC(C)(C)O
• Target: Reactive Oxygen Species,STAT,Nrf2,ROS
• Solubility: DMSO:50 mg/mL (116.69 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.67 mM)

Bioactivity

• In Vitro:
  Meanwhile, the root bark of the plant furnished six xanthones, namely alpha-mangostin (2), beta-mangostin (3), gamma-mangostin (4), Garcinone D (5), mangostanol (6), and gartanin (7). The hexane and chloroform extracts of the root bark of G. mangostana as well as the hexane extract of the stem bark were found to be active against the CEM-SS cell line. gamma-Mangostin (4) showed good activity with a very low IC(50) value of 4.7 microg/ml, while alpha-mangostin (2), mangostanol (6), and Garcinone D (5) showed significant activities with IC(50) values of 5.5, 9.6, and 3.2 microg/ml, respectively

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Garcinone D, inhibit, Keap1-Nrf2, NF-κB, p65, ReactiveOxygenSpecies, Reactive Oxygen Species, STAT3, STAT

Compound Identifiers

PubChem CID

5495926