Garcinone C

SKU: orb1297366

Description

Garcinone C, a xanthone from Garcinia oblongifolia, acts as an acetylcholinesterase (AChE) inhibitor and exhibits cytotoxic activity against certain cancer cell lines in vitro. Its documented anti-inflammatory and tissue-healing properties make it a compound of interest for pharmacological research.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 76996-27-5
• MW: 414.45
• Purity: 98.93% (May vary between batches)
• Formula: C₂₃H₂₆O₇
• SMILES: CC(C)=CCc1c(O)cc2oc3cc(O)c(O)c(CCC(C)(C)O)c3c(=O)c2c1O
• Target: Antifection,ATM/ATR,Hedgehog/Smoothened,AChR,CDK,STAT

Bioactivity

• In Vitro:
  Garcinone C is active against both of pathogenic (MIC =100 μg/ml) and non-pathogenic leptospira (MIC = 200 μg/ml). Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3, and CDK7. Garcinone C significantly inhibits cell viability of the human nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1, and HONE1 in a time‑ and dose‑dependent manner.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclin dependent kinase, CDK, CDK7, AChR, ATR, ATM, ATM and RAD3 related, ATM/ATR, Ataxia telangiectasia mutated, Antifection, Garcinone C, Inhibitor, inhibit, STAT, STAT3

Compound Identifiers

PubChem CID

44159808