Garcinol

SKU: orb1309641

Description

Garcinol, a polyisoprenylated benzophenone from Garcinia indica, is a dual HAT (p300/CBP and PCAF) and cholinesterase (AChE and BChE) inhibitor. Its broad activity profile underpins research into its anti-inflammatory and anti-cancer mechanisms, with studies demonstrating efficacy in both cellular and animal models of disease.

Research Area

Cell Biology, Epigenetics & Chromatin, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 78824-30-3
• MW: 602.80
• Purity: >98%
• Formula: C₃₈H₅₀O₆
• SMILES: CC(C)=CC[C@@H](C[C@@]12C[C@@H](CC=C(C)C)C(C)(C)[C@@](CC=C(C)C)(C(=O)C(C(=O)c3ccc(O)c(O)c3)=C1O)C2=O)C(C)=C
• Target: Acetyltransferase
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Bioactivity

• Target IC50:
  BChE:7.39 µM |AChE:0.66 µM
• In Vivo:
  Garcinolinduces significant inhibition of tumor growth.
• In Vitro:
  Garcinol (10-50 μM; 24-72 hours) induces apoptosis and inhibits the proliferation of HNSCC cells in a time- and dose-dependent manner, specifically in the cell lines CAL27 and UMSCC1. Additionally, Garcinol (50 μM; 1-6 hours) suppresses the phosphorylation and degradation of constitutive IκBα in a time-dependent manner.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AChE, BChE, anti-cancer, anti-cholinesterase, anti-inflammatory, Apoptosis, Cholinesterase (ChE), inhibit, Inhibitor, indica, PCAF, Garcinia, Garcinol, HAT, HATs, Histone Acetyltransferase, HistoneAcetyltransferase, EndogenousMetabolite, Endogenous Metabolite

Compound Identifiers

PubChem CID

174159