Ganetespib

SKU: orb1305731

Description

Ganetespib

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 888216-25-9
• MW: 364.4
• Purity: >98%
• Formula: C₂₀H₂₀N₄O₃
• SMILES: CC(C)c1cc(-c2n[nH]c(=O)n2-c2ccc3n(C)ccc3c2)c(O)cc1O
• Target: HSP (Heat shock protein)
• Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Bioactivity

• Target IC50:
  HSP90:4 nM
• In Vivo:
  Ganetespib was able to exhibit cytotoxicity at the nanomolar level, inhibiting cell proliferation while inducing apoptosis in a variety of human anti-receptor tyrosine kinase inhibitor and tapepermycin-resistant cancer cell lines. In MG63 cell line (IC50=43 nM), Ganetespib inhibited cell growth. In C2 (IC50=19 nM) and BR canine malignant mast cells (IC50=4 nM), Ganetespib induced apoptosis.
• In Vitro:
  Ganetespib was able to exhibit cytotoxicity at the nanomolar level, inhibiting cell proliferation while inducing apoptosis in a variety of human anti-receptor tyrosine kinase inhibitor and tapepermycin-resistant cancer cell lines. In MG63 cell line (IC50=43 nM), Ganetespib inhibited cell growth. In C2 (IC50=19 nM) and BR canine malignant mast cells (IC50=4 nM), Ganetespib induced apoptosis.
• Cell Research:
  A total of 1.5 × 103 OSA cells are seeded in 96-well plates in 10% serum-containing complete medium and incubated overnight to determine the 50% inhibitory concentrations. Plates are, harvested at day 5 following 0.001, 0.005, 0.01, 0.05, 0.1, 0.5 and 1 μM Ganetespib, treatment and analyzed. Fluorescence measurements are made using a plate reader with excitation at 485 nm and emission detection at 530 nm. Relative cell number is calculated as a percentage of the control wells: absorbance of sample/absorbance of DMSO treated cells × 100.(Only for Reference)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

STA-9090

Compound Identifiers

PubChem CID

135564985