gamma-Tocotrienol

SKU: orb1218846

Description

gamma-Tocotrienol is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant. It shows antitumor and antihypertensive effects in vivo.

Key Properties

• CAS Number: 14101-61-2
• MW: 410.64
• Purity: >98% (HPLC)
• Formula: C₂₈H₄₂O₂
• SMILES: OC1=C(C)C(C)=C2C(CC[C@](CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)(C)O2)=C1
• Target: Others
• Solubility: DMSO:100 mg/mL (243.53 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  γ-Tocotrienol’s liposomal formulation, GT3-Nano (20 mol% γ-Tocotrienol), (10 mg/kg, 6 mol%; i. v. ; single dose, observed for 100 d) is highly effective in mitigating the marrow-suppressive effects of sublethal and lethal TBI in mice. GT3-Nano (50 mg/kg; i. v. ;) can facilitate rapid recovery of hematopoietic components in mice treated with the endoradiotherapeutic agent 153Sm-EDTMP. Animal model: C57/BL6 mice (6-8 weeks old) treated with the whole-body irradiation. Dosage: 16, 24, 32, and 50 mg/kg. Administration: Intravenous injection; observed mice for 100 days. Result: Demonstrated dose-dependent radioprotection, achieving 90% survival at 50 mg/kg against lethal 9-Gy of total-body irradiation (TBI). And upregulated progenitor bone marrow cells MPP2 and CMP in GT3-Nano-treated mice.
• In Vitro:
  γ-Tocotrienol (25 μM; 24 h) effectively inhibits the expression levels of mdr1 mRNA and P-gp protein, (25 μM and 50 μM; 24 h) suppresses mdr1 promoter activity and the efflux activity of P-gp as well. γ-Tocotrienol (25 μM and 50 μM; 24 h) reduces the activation of NF-κB signaling pathway and the transcriptional activity of NF-κB. γ-tocotrienol (50 μM; 48 h) effectively inhibits the process of nuclear translocation of p65 which was induced by TNFα. Immunofluorescence Cell line: MCF-7/Adr cells. Concentration: 50 μM. Incubation time: 48 hours. Result: Decreased the red fluorescence of p65 in the nucleus, indicating nuclear translocation inhibiton of p65 induced by TNFα.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Plastochromanol | D-gamma-Tocotrienol | gamma-Tocotrienol | gamma Tocotrienol | gammaTocotrienol

Quick Database Links

Gene Symbol

Others