Galocitabine

SKU: orb1700531

Description

Galocitabine (Neofrutulon) is a thymidylate synthase inhibitor investigated as a potential anticancer agent. It has been studied in vitro for its cytotoxic effects on tumor cell lines and in vivo within preclinical cancer models, highlighting its research application in oncology.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 124012-42-6
• MW: 439.39
• Purity: 98.93% (May vary between batches)
• Formula: C₁₉H₂₂FN₃O₈
• SMILES: O[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)N=C(NC(=O)C3=CC(OC)=C(OC)C(OC)=C3)C(F)=C2
• Target: DNA/RNA Synthesis,Others
• Solubility: DMSO:50 mg/mL (113.79 mM)

Bioactivity

• In Vivo:
  We performed 4-week toxicity studies of capecitabine (N(4)-pentyloxycarbonyl-5'-deoxy-5-fluorouridine), galocitabine (trimethoxybenzyl-5'-deoxy-5-fluorocytidine), 4 different fluoropyrimidine carbamate analogs. Four-week toxicity data for capecitabine in rats and mice were also obtained for comparison. Capecitabine, galocitabine, butyl, and isopentyl analogs showed similar toxicities in hematopoietic and intestinal organs at 1.0 mmol/kg. These compounds showed slight toxicity at 0.5 mmol/kg and no toxicity at 0.1 mmol/kg.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Galocitabine, Neofrutulon, RO091390, RO-091390, RO-09-1390, RO 091390

Compound Identifiers

PubChem CID

65950